Tossup
SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this process by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori Ohsumi a Nobel Prize in 2016. In yeast, this process is regulated by ATG proteins, and may be induced via starvation. During this process, large vesicles bind to lysosomes, whose hydrolytic enzymes break down defective proteins and organelles. For 10 points, name this process in which a cell digests its own components. ■END■
Buzzes
Summary
| Tournament | Edition | TUH | Conv. % | Neg % | Average Buzz |
|---|---|---|---|---|---|
| California | 2025-02-01 | 3 | 67% | 100% | 111.50 |
| Florida | 2025-02-01 | 2 | 50% | 50% | 122.00 |
| Lower Mid-Atlantic | 2025-02-01 | 6 | 50% | 67% | 114.33 |
| Midwest | 2025-02-01 | 6 | 83% | 50% | 92.40 |
| North | 2025-02-01 | 3 | 33% | 100% | 122.00 |
| Northeast | 2025-02-01 | 5 | 60% | 20% | 106.33 |
| Overflow | 2025-02-01 | 5 | 80% | 60% | 86.75 |
| South Central | 2025-02-01 | 2 | 100% | 0% | 96.00 |
| Southeast | 2025-02-01 | 4 | 75% | 50% | 104.33 |
| UK | 2025-02-01 | 10 | 70% | 20% | 99.43 |
| Upper Mid-Atlantic | 2025-02-01 | 8 | 50% | 75% | 110.25 |
| Upstate NY | 2025-02-01 | 3 | 33% | 67% | 120.00 |