autophagy - Northeast

Tossup

SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this process by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori Ohsumi a Nobel Prize in 2016. (10[1])In yeast, this process is regulated by ATG proteins, and may be induced via starvation. During this process, large vesicles (-5[1])bind to lysosomes, whose hydrolytic enzymes break down defective proteins and organelles. For 10 points, name this process in which a cell digests its own components. ■END■ (10[2]0[2])

ANSWER: autophagy [or autophagocytosis; reject “phagocytosis”]

= Average correct buzz position

Back to tossups

Buzzes

Player	Team	Opponent	Position	Value
Jonathan Huang	MIT A	Tufts A	75	10
William Parocai	Dartmouth A	Brown A	95	-5
Jon Suh	Harvard A	Brandeis A	122	10
Max Neal	Harvard B	Brandeis B	122	0
Eren Michelet	BU	UMass Boston	122	0
Mason Yu	Brown A	Dartmouth A	122	10

Summary

Tournament	Edition	TUH	Conv. %	Neg %	Average Buzz
California	2025-02-01	3	67%	100%	111.50
Florida	2025-02-01	2	50%	50%	122.00
Lower Mid-Atlantic	2025-02-01	6	50%	67%	114.33
Midwest	2025-02-01	6	83%	50%	92.40
North	2025-02-01	3	33%	100%	122.00
Northeast	2025-02-01	5	60%	20%	106.33
Overflow	2025-02-01	5	80%	60%	86.75
South Central	2025-02-01	2	100%	0%	96.00
Southeast	2025-02-01	4	75%	50%	104.33
UK	2025-02-01	10	70%	20%	99.43
Upper Mid-Atlantic	2025-02-01	8	50%	75%	110.25
Upstate NY	2025-02-01	3	33%	67%	120.00