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Round 5: Tossup 20

SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this process by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori Ohsumi a Nobel Prize in 2016. In yeast, this process is regulated by ATG proteins, and may be induced via starvation. During this process, (-5[2])large vesicles bind to lysosomes, whose hydrolytic enzymes (10[1])break down defective proteins and organelles. For 10 points, name this process in which a cell digests (-5[1])its own components. ■END■ (10[1])

ANSWER: autophagy [or autophagocytosis; reject “phagocytosis”]
<Ohio State A, Biology> | Packet-G_Chicago-B_Ohio-State-A_UW-B
= Average correct buzzpoint

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Buzzes

PlayerTeamOpponentBuzzpointValue
Scarlet RutterClaremont BClaremont A93-5
Swapnil GargUC Berkeley AUC Berkeley B93-5
Kevin ParkClaremont AClaremont B10110
Terrence HanUCLAUCSD118-5
Vinu HariharUC Berkeley BUC Berkeley A12210

Summary

TournamentEditionMatchHeardConv. %Neg %Avg. Buzz
California2025-02-01✓367%100%111.50
Florida2025-02-01✓333%33%122.00
Lower Mid-Atlantic2025-02-01✓650%67%114.33
Midwest2025-02-01✓683%50%92.40
North2025-02-01✓333%100%122.00
Northeast2025-02-01✓560%20%106.33
Overflow2025-02-01✓580%60%86.75
South Central2025-02-01✓2100%0%96.00
Southeast2025-02-01✓475%50%104.33
UK2025-02-01✓1070%20%99.43
Upper Mid-Atlantic2025-02-01✓850%75%110.25
Upstate NY2025-02-01✓333%67%120.00