autophagy - Southeast

Tossup

SAR405 regulates this process by inhibiting Vps34, which activates a protein complex containing MLST8 and PRAS40. HSC70 initiates one form of this process (-5[1])by binding to proteins with a KFERQ (“K-F-E-R-Q”) motif and directing them to a LAMP2A multimeric complex. That chaperone-mediated form of this process is important for regulating cells under mechanical stress like muscle cells. By phosphorylating ULK1, mTOR (“M-tor”) downregulates this process. A study of this process earned Yoshinori (10[1])Ohsumi a Nobel Prize in 2016. In yeast, this process is regulated by ATG proteins, and may be induced via starvation. (-5[1])During this process, large vesicles bind to lysosomes, whose hydrolytic enzymes break down defective proteins and organelles. For 10 points, name this process in which a cell digests its own components. ■END■ (10[2]0[1])

ANSWER: autophagy [or autophagocytosis; reject “phagocytosis”]

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Buzzes

Player	Team	Opponent	Position	Value
Rohan Dalal	Georgia Tech C	Georgia Tech A	22	-5
Jack Lewis	Bruin A	Georgia Tech D	69	10
Harris Beckner	Alabama A	Louisville A	90	-5
Tianyu Xu	Georgia Tech A	Georgia Tech C	122	10
Parker McCoig	Tennessee A	Vanderbilt A	122	0
Brina Ratangee	Vanderbilt A	Tennessee A	122	10

Summary

Tournament	Edition	TUH	Conv. %	Neg %	Average Buzz
California	2025-02-01	3	67%	100%	111.50
Florida	2025-02-01	2	50%	50%	122.00
Lower Mid-Atlantic	2025-02-01	6	50%	67%	114.33
Midwest	2025-02-01	6	83%	50%	92.40
North	2025-02-01	3	33%	100%	122.00
Northeast	2025-02-01	5	60%	20%	106.33
Overflow	2025-02-01	5	80%	60%	86.75
South Central	2025-02-01	2	100%	0%	96.00
Southeast	2025-02-01	4	75%	50%	104.33
UK	2025-02-01	10	70%	20%	99.43
Upper Mid-Atlantic	2025-02-01	8	50%	75%	110.25
Upstate NY	2025-02-01	3	33%	67%	120.00