Tossup

Assays for measuring the activity of this compound based on BRET and FRET methods include CAMYEL and FlCRhR (10[1])(“flicker”). By forcing one enzyme to bind to calmodulin, a virulence factor produced by members of the genus Bordetella increases levels of this compound. The enzyme that produces this compound can be stimulated using Forskolin, and is activated by the A subunit of cholera toxin, which increases intracellular levels of this compound by over 100-fold. Low glucose levels cause this molecule to allosterically bind to CRP (-5[1])as part of a positive regulation mechanism. Phosphodiesterases most commonly act on this compound, which is necessary for the activity of protein kinase A. (10[2])For 10 points, name this secondary messenger molecule made from ATP by adenylyl cyclase. ■END■ (10[1]0[1])

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Summary